Several earlier experimental studied in animals suggest that a regulatory influence on leukopoiesis may be exerted from the central nervous system, especially hypothalamus. Though many authors indicate various regions which may be engaged in the regulation of the number of the white blood cells in the peripheral blood, no definite area is documented.
Author made the experimental studied to find out the sites which may be responsible for the control of the white blood cells in the peripheral blood, through the stimulation on the various parts of the central nervous system such as anterior hypothalamus, mid-hypothalamus, posterior hypothalamus, mid brain, median eminence, hippocampus, mammillary body, preoptic area and amygdala with the injection of pertussis vaccine according to Choi´s stereotaxie coordinates. White male rabbits weighing 1.8kg were used as experimental animals.
The following results were obtained.
1. There was a rapid and significant reduction of the number of the white blood cells in the peripheral blood by the injection of pertussis vaccine into the anterior hypothalamus and intravenous administration.
2. Comparing the above two, the degree of reduction on the number of the white blood cells was more rapid and greater in case of injection into the anterior hypothalamus than given intravenously.
3. During the initial leucopenic response to pertussis vaccine, the main acute effect was lymphopenia.
4. In other areas a slight degree of leukocytosis and temporary lymphopenia were observed without significance.
With the above mentioned experimental findings, the author concluded that the anterior hypothalamus may regulatory function on the number of the white blood cells in the peripheral blood.
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